Abstract:

Hemorrhagic shock caused by massive fluid loss in patients with severe fever and trauma is one of the most important factors leading to the death of patients. At present, the treatment of hemorrhagic shock caused by severe burns and trauma is mainly based on fluid resuscitation to maintain tissue perfusion of vital organs of the body and protect organ function. However, the implementation of this strategy often can not guarantee timeliness (especially in war and severe disasters). Therefore, the ability to treat early and promptly with anti-shock medication at the scene of an emergency, which would then rapidly stabilise the casualty in a short time, make injury judgements and buy valuable time for subsequent treatment, is an urgent issue that needs to be addressed. Valproic acid, a histone deacetylase inhibitor (HDACi), is one of the research hotspots of domestic and foreign researchers in recent years. Recent studies have found that valproic acid can effectively resist tissue and organ damage secondary to ischemia and hypoxia, improve the body′s tolerance to ischemia and hypoxia and inflammatory attack, and improve the survival rate. In this paper, the research progress of the anti-shock effect of valproic acid and its related mechanisms that regulation of the degree of histone acetylation, regulation of phosphoinositide 3-kinase(PI3K)/Akt signaling pathway, regulation of 2, 3-bisphosphoglycerate concentration in erythrocytes, and inhibition of inflammatory responses and inflammatory factors were discussed.

Key words: Shock, Burns, Wounds and injuries, Valproic acid, Histone deacetylase inhibitor