Application and challenges of exosomes drived from mesenchymal stem cells in wound healing

doi:10.3877/cma.j.issn.1673-9450.2021.01.001

Abstract

Abstract:

Mesenchymal stem cells (MSC) can effectively promote the healing of various wounds and have reached the stage of clinical trials. Further studies have found that exosomes secreted by MSC by paracrine mechanism also have biological effects equivalent to MSC. "Cell-free" therapy based on exosomes drived from MSC has broad application prospects, but the controversy and challenges it faces are also worthy of attention. This paper briefly reviewed the application and existing problems of MSC and exosomes drived from MSC, furthermore, the influence of microenvironment was analyzed and discussed.

Key words: Stem cells, Wound healing, Therapeutic uses, Exosomes, Challenge

Fang Qi, Dali Wang. Application and challenges of exosomes drived from mesenchymal stem cells in wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(01): 1-5.

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