Effect of platelet-rich plasma on wound healing in diabetic foot

doi:10.3877/cma.j.issn.1673-9450.2022.02.007

Abstract

Abstract:

Objective

To explore the role of platelet-rich plasma(PRP) in wound repair of diabetec foot.

Methods

One hundred and twenty patients with diabetic foot admitted in People′s Hospital of Xinjiang Uygur Autonomous Region from February 2019 to January 2020 were selected. The patients were randomly divided into two groups: control group and study group according to the different ways of treatment, with each group 60 cases. All patients were treated with anti-infective, blood glucose control and taking photos after surgical debridement. Control group: conventional dressing change therapy; study group: PRP was applied to the wound evenly and completely, all patients covered the wound with vaseline gauze, changed/debridement as needed, until the wound was completely healed. The wound healing rate, complete wound healing time, positive rate of inflammatory reaction and times of dressing change/debridement were statistically analyzed in the two groups, and the data were analyzed with t test and chi-square test.

Results

On the 6th, 9th and 18th day after dressing change, the wound healing rate of the study group[(18.90±7.18)%, (58.49±9.80)%, (96.70±5.39)%]were better than those of the control group[(14.76±6.79)%, (43.76±7.29)%, (80.51±7.40)%], the differences were statistically significant (t=2.814, 8.092, 11.860; P<0.05), and the complete wound healing time of the study group[(21.49±3.18) d] was shorter than the control group[(27.46±3.79) d], the difference was statistically significant(t=8.094, P<0.05). The positive rate of inflammatory reaction in the Study group (8.33%) was significantly lower than that in the latter group (35.00%), the difference between the two groups was statistically significant (χ²=6.534, P<0.05). The times of dressing change/debridement in the study group[(7.19±1.08), (2.28±0.59)times] were lower than those in the control group[(9.68±1.47), (5.37±1.29)times], the differences were statistically significant(t=4.583, 7.282; P<0.05).

Conclusion

The external application of platelet-rich plasma is more effective in the repair of diabetic foot wounds, which can shorten the healing time, reduce the incidence of posetive inflammatory reaction and the Times of dressing change/debridement.

Key words: Platelet-rich plasm, Diabetic foot, Foot ulcer, Wound healing

Jian Zhang, Xiaolong Liu, Tianjian Zha, Lihua Liu. Effect of platelet-rich plasma on wound healing in diabetic foot[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(02): 131-134.

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References 21

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组别	例数	创面愈合率(%)			创面完全愈合时间(d)
组别	例数	换药后第6天	换药后第9天	换药后第18天	创面完全愈合时间(d)
研究组	60	18.90±7.18	58.49±9.80	96.70±5.39	21.49±3.18
对照组	60	14.76±6.79	43.76±7.29	80.51±7.40	27.46±3.79
t值		2.814	8.092	11.860	8.094
P值		0.012	0.001	0.001	0.001

组别	例数	创面愈合率(%)			创面完全愈合时间(d)
组别	例数	换药后第6天	换药后第9天	换药后第18天	创面完全愈合时间(d)
研究组	60	18.90±7.18	58.49±9.80	96.70±5.39	21.49±3.18
对照组	60	14.76±6.79	43.76±7.29	80.51±7.40	27.46±3.79
t值		2.814	8.092	11.860	8.094
P值		0.012	0.001	0.001	0.001

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