To explore the clinical efficacy of alginate dressing combined with recombinant human granulocyte macrophage colony stimulating factor(rhGM-CSF) gel and Mupirocin ointment mixture to cover the wound surface, and then hydrocolloid dressing was used to seal the tendon and bone exposed wounds.

From October 2018 to May 2020, in the Department of Burns and Plastic and Wound Treatment Center of Dazhou Central Hospital, 50 patients with wounds area larger than 0.5 cm² were divided into the control group and the intervention group by lottery method, with 25 patients in each group. Time for granulation tissue to completely cover exposed tendons and bones, wound healing time and visual analogue scale(VAS) in the first 3 dressing changes were evaluated in both groups. The data was analyzed by t test and chi-square test.

Time for granulation tissue to completely cover exposed tendons and bones in intervention group was (20.556±10.214) d, which was lower than that of the control group[(28.040±11.929) d], the difference was statistically significant(t=2.436, P=0.019); wound healing time of the intervention group was (30.778±12.762) d, which was shorter than that of the control group [(40.600±17.231) d], the difference was statistically significant (t=2.348, P=0.023); VAS in the first 3 dressing changes in intervention group was (1.893±0.924) points, which was lower than that of the control group[(5.067±1.223) points], the difference was statistically significant(t=17.933, P<0.001).

Alginate dressing combined with the mixture of rhGM-CSF and Mupiroxine ointment, and then closed wound with hydrocolloid dressing can promote the growth of granulation tissue, cover of tendon and bone and wound healing, reduce pain during dressing change and improve the efficiency of dressing change, as well as reduce the flap surgery, providing a new technique for patients whose wounds do not meet the surgical conditions and who refuse surgeries.Hence, it is worth developing this technique in primary hospitals.