Research progress on the role of antimicrobial peptides in diabetic wound healing

doi:10.3877/cma.j.issn.1673-9450.2024.01.015

Abstract

Abstract:

Antimicrobial peptides (AMPs) are amphipathic peptides with antibacterial activity existing in organisms. AMPs can promote the healing of diabetic wounds by participating in regulating the inflammatory reaction of wounds, promoting cell proliferation, migration and angiogenesis, and regulating wound tissue remodeling, and has gradually become a promising drug in the field of wound healing. In this article, the antibacterial mechanism of AMPs, the mechanism of promoting diabetic wound healing and the current optimal design of AMPs on wound healing were reviewed and summarized, and the future prospect of developing effective new AMPs was discussed.

Key words: Antimicrobial peptides, Antibiosis, Wound healing, Optimization, Diabetes

Rongqin Feng, Peng Wang, Yu Li, He Lu, Xiaozhi Bai, Juntao Han. Research progress on the role of antimicrobial peptides in diabetic wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(01): 78-82.

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URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2024.01.015

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