To retrospectively study the effect of chymotrypsin combined with hydrophilic fiber dressing on chronic wound healing.

The clinical data of 98 cases with chronic wounds hospitalized in the Department of Burns and Plastic Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People′s Hospital from January 2018 to October 2021 were collected. Among them, 28 cases were treated with dressing change for routine treatment and were included in the control group; 38 cases were treated with chymotrypsin and were included in the chymotrypsin group; 32 cases were treated with chymotrypsin combined with hydrophilic fiber dressing and were included in the compound dressing change group. The wound healing time, dressing change times, average total treatment cost, incidence of wound infection and pain score were compared among the three groups. Data were processed with one-way analysis of variance, t test and chi-square test.

There were statistically significant differences in average wound healing time, average dressing change times, and average pain score among compound dressing change group, chymotrypsin group and control group (F=91.94, 69.36, 9.063; P<0.05). There were no statistically significant differences in the average total treatment cost and the incidence of infection among the three groups (F=1.117, χ²=4.256; P>0.05). The average wound healing time in the compound dressing group was (17.2±0.4) d, which was significantly lower than that in the control group [(24.9±0.5) d] and chymotrypsin group [(24.1±0.5) d], and the differences were statistically significant(t=11.47, 13.31; P<0.05). The average dressing change times in the compound dressing group was (8.25±0.29) times, which was significantly lower than that in the chymotrypsin group [(12.74±0.28) times] and the control group [(12.71±0.49) times] , and the differences were statistically significant(t=11.21, 8.27; P<0.05). The pain score of patients in the compound dressing change group was (1.9±0.2) points, which was significantly lower than that in the chymotrypsin group [(2.6±0.2) points] and the control group [(3.1±0.2) points] , the differences were statistically significant (t=2.761, 4.228; P<0.05).

Chymotrypsin combined with hydrophilic fiber dressing can effectively promote the clearance of chronic wound necrotic tissue, promote the growth of fresh granulation tissue, reduce the infection rate, and do not increase the total cost of treatment. Therefore, it is worthy of further research and clinical promotion.