To observe the clinical effect of lacunar soft tissue defect of the limbs repairing by autologous fat granule transplantation.

From September 2017 to June 2019, 14 patients with lacunar soft tissue defects were treated in the Department of Trauma and Micro Orthopedics, Zhongnan Hospital of Wuhan University, the defect area was 1.5 cm×2.0 cm-4.0 cm×6.0 cm, the defect depth was 3.0-7.0 cm. The fat particles were prepared by Coleman method for transplantion after thorough debridement, and the fat particles were injected into the soft tissue around the defect and filled in the cavity.The surface was covered with vaseline gauze and the vaseline gauze was opened every week to observe the change of the tissue defect site. Continuous follow-up was conducted to understand the wound repair until the wound healing.

All patients were followed up for 12 weeks. A large number of granulation tissue growth was observed at the defect site after 2 weeks of treatment, and the defect area was reduced about (47.5±5.5)%. In 12 cases, the area of skin and soft tissue defect was narrowed and healed directly after treatment, with an average healing time of (24.2±4.5) d; in one case, the skin and soft tissue defect was accompanied by bone defect after treatment for one week, partial transplantation of fat necrosis and local flap transplantation were performed for healing; one case was infected with fat liquefaction and necrosis 5 days after the operation. Debridement was performed to control the infection and heal after wound dressing.

Fat transplantation has a positive effect on the repair of limb lacunar soft tissue, can promote the growth of granulation tissue, accelerate soft tissue reconstruction, and is suitable for limb lacunar soft tissue defects.