Clinical curative effect observation of recombinant human granulocyte-macrophage colony-stimulating factor gel on wound healing in patients with deep partial thickness burns

doi:10.3877/cma.j.issn.1673-9450.2016.03.012

Abstract

Abstract:

Objective

To observe the effect of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) gel for deep partial thickness burns.

Methods

Fifty patients from the Fourth Clinical Medical College of Peking University at December 2013 to November 2014 with deep partial thickness burns at 10%-30% total body surface area (TBSA) were randomly assigned into treatment group (conventional debridement and application of rhGM-CSF and mupirocin ointment) and control group (conventional debridement and application of mupirocin ointment), with each group of 25 cases. The complete wound healing time were compared, and wound healing rate were compared in the treatment of 7th, 14th, 21th, 28th days by Chi-square test and t test, as well as systemic situation and adverse reactions were observed.

Results

The complete wound healing time in the treatment group (19.6±2.5)d was shorter than that in the control group (27.3±3.4)d, the difference was statistically significant(P<0.05). The wound healing rates in the treatment group (29.8±4.6)%, (74.0±7.1)%, (98.2±2.6)% and (100.0±0.0)%, were respectively higher than those in the control group (20.6±4.5)%, (52.0±8.2)%, (79.6±5.0)% and (97.3±2.6)% in the treatment of 7th, 14th, 21th, 28th days, the differences were statistically significant(t=-7.090, -10.050, -16.289, -4.993, P values were less than 0.05). During the research, the vital signs, liver and kidney functions of patients in two groups were all normal without adverse reactions.

Conclusion

Using rhGM-CSF gel can accelerate wound healing in patients with deep partial thickness burn.

Key words: Burns, Wound healing, Granulocyte-macrophage colony-stimulating factor, Recombination, Vital signs

Chunquan Wen, Xiaozhuo Zhao, Guoan Zhang. Clinical curative effect observation of recombinant human granulocyte-macrophage colony-stimulating factor gel on wound healing in patients with deep partial thickness burns[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2016, 11(03): 215-218.

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Figures/Tables 2

References 24

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组别	例数	年龄(岁)	性别(例)		创面部位(例)
组别	例数	年龄(岁)	男	女	下肢	上肢	躯干
试验组	25	32.0±3.7	21	4	18	4	3
对照组	25	35.0±6.7	20	5	16	5	4
t/χ²值	?	－1.818	0.136		0.372
P值	?	0.078	0.713		0.830

组别	例数	年龄(岁)	性别(例)		创面部位(例)
组别	例数	年龄(岁)	男	女	下肢	上肢	躯干
试验组	25	32.0±3.7	21	4	18	4	3
对照组	25	35.0±6.7	20	5	16	5	4
t/χ²值	?	－1.818	0.136		0.372
P值	?	0.078	0.713		0.830

组别	创面愈合率
组别	治疗7 d	治疗14 d	治疗21 d	治疗28 d
试验组	29.8±4.6	74.0±7.1	98.2±2.6	100.0±0.0
对照组	20.6±4.5	52.0±8.2	79.6±5.0	97.3±2.6
t值	－7.090	－10.050	－16.289	－4.993
P值	<0.05	<0.05	<0.05	<0.05

组别	创面愈合率
组别	治疗7 d	治疗14 d	治疗21 d	治疗28 d
试验组	29.8±4.6	74.0±7.1	98.2±2.6	100.0±0.0
对照组	20.6±4.5	52.0±8.2	79.6±5.0	97.3±2.6
t值	－7.090	－10.050	－16.289	－4.993
P值	<0.05	<0.05	<0.05	<0.05

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