Advances in research on the involvement of eccrine sweat glands in wound healing

doi:10.3877/cma.j.issn.1673-9450.2022.05.013

Abstract

Abstract:

Stem cells from both the epidermis and hair follicles are involved in the healing of skin wounds, but little is known about the role of eccrine sweat glands in the process of wound healing. This paper briefly describes the structural characteristics and developmental process of eccrine sweat glands, the role and mechanism of eccrine sweat gland cells involved in wound re-epithelialisation and vascularisation, and experimental studies on the in vitro construction of sweat gland-like organs. The analysis of these experimental studies has shown that eccrine sweat glands not only have a role in the regulation of body temperature through the secretion of sweat, but also play an important role in the re-epithelialisation and vascularisation of wounds, suggesting that the cultivation of sweat gland-like organs in vitro can not only lead to the reconstruction of skin function, but also to the healing of wounds.

Key words: Eccrine sweat gland, Wound healing, Organoid, Re-epithelialization, Vascular regeneration

Qiangqiang Shang, Lingfeng Wang, Te Ba, Shengjun Cao, Biao Zhou, Quan Li, Zhihui Hou, Zengqiang Yan, Qiang Chen. Advances in research on the involvement of eccrine sweat glands in wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(05): 450-453.

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https://zhssyxfzz.cma-cmc.com.cn/EN/Y2022/V17/I05/450

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